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New England Journal of Medicine, Volume 394, Issue 16, Page 1595-1607, April 23, 2026.

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A 60-year-old woman with follicular lymphoma was evaluated for swelling and proteinuria that had persisted for 2 weeks. The patient’s plasma was clear at 37°C but turbid at 4°C. A kidney biopsy was performed.

Among men with locally advanced prostate cancer, transdermal estradiol was noninferior to LHRH agonists for 3-year metastasis-free survival and led to a lower incidence of hot flashes but a higher incidence of gynecomastia.

In a placebo-controlled trial involving patients with noncardioembolic ischemic stroke or high-risk TIA, asundexian added to antiplatelet therapy led to a lower risk of ischemic stroke without increasing major bleeding.

In a phase 3 trial, ianalumab plus eltrombopag led to a longer time to treatment failure than placebo plus eltrombopag, with a stable platelet response at 6 months in a higher percentage of patients with 9 mg/kg of ianalumab than with placebo.

Combined oral contraceptives and hormone-replacement therapy increase the risk of venous thromboembolism, although the absolute risk is low. Transdermal estradiol and micronized progesterone carry lower risk.

Despite the implementation of efficacious interventions for secondary prevention, patients with ischemic stroke or transient ischemic attack (TIA) remain at substantial residual risk for short- and long-term recurrent ischemic stroke and coronary events.1,2 Approximately three quarters of ischemic strokes or TIAs are noncardioembolic and may be attributable to...

The Trump administration’s wide-ranging actions to dismantle U.S. environmental regulations will cause long-lasting health harms, disproportionately affecting low-income and other vulnerable groups.

In a patient with metastatic cervical cancer treated with the nectin-4–targeted antibody–drug conjugate bulumtatug fuvedotin, a new hepatic lesion proved to be pseudoprogression and resolved with continued therapy.

In a phase 1 trial of first-line zongertinib for HER2-mutated non–small-cell lung cancer, an objective response occurred in 76% of patients, with a median progression-free survival of 14.4 months.

The discovery that many lung cancers are driven by a single dominant constitutively activated “driver” oncogene represented a quantum leap in the therapy of lung cancer. Potent small molecules were developed that could turn off these genes, with dramatic clinical therapeutic efficacy. Before their discovery, cancer therapeutics were identified by...

Post-thrombotic syndrome is the most common chronic complication of deep-vein thrombosis (DVT), affecting 20 to 50% of patients with DVT and causing debilitating symptoms involving the limbs — including pain, swelling, skin changes, and venous ulcers — that substantially reduce quality of life and impose considerable socioeconomic burden.1 ...

Among adults with persistent or chronic ITP, the incidence of adverse events with mezagitamab appeared to be similar to that with placebo. Mezagitamab treatment appeared to result in increased platelet counts at all three doses tested.

In a phase 1 trial of setidegrasib, a KRAS G12D degrader, 42% of patients had adverse events of grade 3 or higher; 36% of patients with NSCLC and 24% of those with pancreatic cancer had a response.

A study in a mouse model of MYCN-amplified neuroblastoma implicates polyamine levels in affecting the makeup of the proteome and biologic characteristics of the tumor.

An 83-year-old woman with worsening type 2 diabetes presented with a 6-month history of painful rash. Hyperpigmented plaques with coalescing erosions and blisters were seen. Abdominal CT revealed a mass in the tail of the pancreas.

In this study, a Cas12a–guide RNA complex was used to target the promoters of HBG1 and HBG2 in autologous stem cells to treat sickle cell disease.

In cisplatin-ineligible patients with muscle-invasive bladder cancer, enfortumab vedotin–pembrolizumab plus surgery led to better event-free survival (74.7%, vs. 39.4%) and overall survival (79.7%, vs. 63.1%) than surgery alone at 2 years.

In this study, a Cas12a–guide RNA complex was used to target the promoters of HBG1 and HBG2 in autologous stem cells to treat transfusion-dependent β-thalassemia.

Transfusion-dependent β-thalassemia and sickle cell disease, both characterized by defective hemoglobin synthesis, are the most common monogenic diseases worldwide. Each year, approximately 60,000 infants are born with transfusion-dependent β-thalassemia, and 500,000 infants receive a diagnosis of sickle cell disease.1,2 Historically, patients with these disorders have rarely survived beyond...

Although bladder preservation with trimodal therapy is a category 1 recommendation in the National Comprehensive Cancer Network (NCCN) guidelines for appropriately selected patients with muscle-invasive bladder cancer, the real-world adoption of this type of therapy in the United States remains disappointingly low. Contemporary data suggest that only half the patients...

In early 2026, 62-year-old Gibraltar resident Paul Buxton had a successful robotic prostatectomy to treat his prostate cancer. His surgeon was 2400 km away in London, UK. In mid-2025, a surgeon in Florida, USA, performed the same surgery on a patient in Angola, Africa—the longest distance telesurgery recorded to date. Once the realm of science fiction, telesurgery is rapidly transforming surgical oncology, with the potential to bridge health equity gaps and overcome health-system barriers, facilitating access to high-quality surgical care in remote and underserved regions and relieving global workforce shortages.

For more than a decade, immune checkpoint inhibitors (ICIs) have played a central part in the treatment landscape of advanced non-small-cell lung cancer (NSCLC).1 These therapies have improved survival both as monotherapy and in combination with chemotherapy and altered expectations for patients with metastatic disease. Yet their benefit is not universal. A substantial proportion of patients (∼18%) derive little or no clinical improvement, and some experience rapid deterioration with primary resistance.

KRAS has long been regarded as an indomitable oncogenic driver which defines a distinct and therapeutically elusive class of solid tumours. The recent advent of direct KRAS inhibitors has fundamentally altered the drug development landscape of KRAS-mutated tumours, including non-small-cell lung cancer (NSCLC). The first entrants in this class used a unique mechanism of action which inhibited KRASG12C by irreversibly binding to its inactive GDP-bound conformation at the switch-II binding pocket (KRASG12C[OFF] inhibitors).

Historically, perioperative cisplatin based neoadjuvant therapy has remained the gold standard for muscle-invasive bladder cancer. In the past 5 years, several practice changing trials have enabled the incorporation of immune checkpoint inhibitors in the perioperative setting for muscle-invasive bladder cancer. The phase 3 NIAGARA study led to the approval of durvalumab in combination with gemcitabine or cisplatin followed by adjuvant immune checkpoint inhibitor monotherapy.1 The CheckMate-274 and AMBASSADOR trials showed improved outcomes in patients treated with adjuvant immune checkpoint inhibitors.

Since 1992, the surgical treatment for melanoma has substantially changed,1 and in clinically negative nodal basin, elective lymph node dissection has been overtaken by the sentinel node biopsy (SNB) followed by complete lymph node dissection in the case of positivity to SNB at the histopathological report. Many different studies have examined these methods, looking at specific subclinical features such as micro-metastases or macro-metastases,2 SNB tumour burden,3 number of SNBs, number of positive non-sentinel lymph nodes, and number of excised non-sentinel lymph nodes.

The study published by Bastiaan M Privé and colleagues in The Lancet Oncology represents, to our knowledge, the first randomised phase 2 trial evaluating lutetium-177–PSMA-617 (177Lu-PSMA-617) in patients with oligometastatic hormone-sensitive prostate cancer (HSPC).1 By showing that 177Lu-PSMA-617 can significantly delay disease progression while maintaining a favourable safety profile, the BULLSEYE trial expands the therapeutic horizon of PSMA-targeted radioligand therapy beyond its established role in metastatic castration-resistant prostate cancer (mCRPC).

Antibody–drug conjugates (ADCs) represent one of the most transformative advances in precision oncology over the past two decades and are increasingly positioned to replace conventional chemotherapy in several indications owing to their favourable balance between efficacy and tolerability. Trastuzumab deruxtecan exemplifies this paradigm shift, having achieved regulatory approvals across multiple HER2 (ERBB2)-expressing or HER2-mutated solid tumours, including breast, gastric, and non-small-cell lung cancers (NSCLCs).

Expansion of genetic testing to the general population is one of the ambitions of the UK Government's 2025 10-year Health Plan for England, as part of a strategy for transition from “sickness to prevention”.1 Identification of individuals at increased cancer risk due to pathogenic variants in cancer susceptibility genes, leading to targeted screening and prioritisation of risk reduction strategies is one potential benefit of this approach. However, there are many outstanding questions about the impact on health-care services.

Kidney cancer is the sixth most common cancer in adults in the UK, with approximately 13 900 new cases every year.1 Kidney cancer incidence rates have almost doubled since the 1990s and are projected to rise further by 2040.2 5-year relative survival for kidney cancer in the UK is below the European average,3 and there is wide variation in provision of kidney cancer care in England and Wales.4 If found early, kidney cancer can be cured, but early diagnosis is challenging as most people (87%) in the UK with stage 1a disease are diagnosed incidentally, having no relevant symptoms.

We read with interest the Article by Giacomo Montagna and colleagues1 evaluating oncological outcomes in patients with residual nodal micrometastatic disease (ypN1mi) following neoadjuvant systemic therapy. Although the study contributes important data on axillary management, the recommendation favouring completion axillary lymph node dissection (ALND) in patients with triple-negative breast cancer warrants cautious interpretation given key limitations and conflicting evidence.

We read with great interest the Article by Giacomo Montagna and colleagues,1 which addresses a pivotal question in contemporary breast cancer care—if axillary lymph node dissection (ALND) can be safely omitted in patients with residual micrometastases (ypN1mi) after neoadjuvant chemotherapy. Their multinational cohort provides much-needed outcome data to inform surgical de-escalation strategies. However, the significantly higher axillary recurrence rate observed in patients with triple-negative breast cancer who did not undergo ALND (8·7% [95% CI 4·4–15·0] vs 2·4% [0·7–6·5]; p=0·018) warrants careful interpretation before this finding influences clinical practice.

We have read the Correspondence from Kefah Mokbel, Fady Sourial, and their colleagues with interest, thank them for their comments, and welcome the opportunity to clarify the points they raise. Among 1585 patients with residual nodal micrometastases (ypN1mi) following neoadjuvant chemotherapy, our study failed to show a short-term oncological benefit from axillary lymph node dissection (ALND), with the exception of patients with triple-negative breast cancer (284 [18%]). The rate of axillary recurrence among the 127 patients who had triple-negative breast cancer but did not undergo completion ALND was higher than it was among the 157 who did (8·7% [95% CI 4·4–15·0] vs 2·4% [0·7–6·5], p=0·018).

Lisa M Wintner and colleagues show that giving clinicians access to EORTC patient-reported outcome (PRO) data during assessment with Common Terminology Criteria for Adverse Events (CTCAE) significantly increased inter-rater reliability for 13 of 17 symptomatic adverse events, with the largest gains in cognitive and psychological domains.1 This pragmatic multinational trial provides timely evidence for integrating PROs into safety assessment workflows.

We thank Jiale Chen and Xiaoyuan Xu for suggesting presentation of absolute risks of Common Terminology Criteria for Adverse Events (CTCAE) grade 2 and above, and 3 and above, symptomatic adverse events and corresponding risk differences between study groups to illustrate the added value of PRO data for adverse event identification. For each adverse event, we calculated the proportion of patients with the highest grade 2 and 3 or above per group, using the higher of the two available ratings (worst toxicity reported).

Wintner LM, Sztankay M, Abdel-Razeq H, et al. Inter-rater reliability of CTCAE assessments with or without EORTC patient-reported outcome data in a mixed cancer population: a multinational, open-label, randomised controlled trial. Lancet Oncol 2026; 27: 233–42—In this Article, the final sentence in the Findings of the Summary should have read “There was no significant difference for pain, diarrhoea, fatigue, and peripheral sensory neuropathy.” In the figure, the box noting exclusions from the intervention group should have read “28 had incomplete CTCAE assessments”.

Sharma DC. India introduces human papillomavirus vaccination. Lancet Oncol 2026; 27: 413—In this News, the in-text affiliations for Ravi Mehrotra and Soumya Swaminathan have been corrected. These corrections have been made to the online version as of March 30, 2026, and the printed version is correct.

On Feb 15 (commemorating the World Childhood Cancer Day), Jordan announced three linked initiatives: a National Cancer Control Strategy 2026–2030, six national paediatric cancer clinical guidelines, and its entry into the Global Platform for Access to Childhood Cancer Medicines. The event was jointly organised by the Ministry of Health and WHO under the patronage of Princess Ghida Talal of the King Hussein Cancer Foundation and King Hussein Cancer Center (KHCC; Amman, Jordan). The event also included participation of civil society organisations supporting patients with cancer (among panellists), to foster meaningful engagement of patients in line with WHO guidance.

On Feb 26, 2026, WHO announced that South Sudan's leadership had signalled renewed political attention to cancer control after Vice President, Josephine Lagu Yanga, met with WHO officials in Juba to discuss strengthening prevention, screening, treatment, and palliative care. The talks came as the country begins to mobilise a more coordinated response to cancer.

On Feb 27, 2026, lawmakers in the UK voted to sign into law the Rare Cancers Bill. The bill was proposed by Scott Arthur, a Member of Parliament for the ruling Labour Party based in Scotland, and a medical doctor. The bill will help accelerate research innovation to improve treatments and survival for rare cancers, including brain tumours and pancreatic cancer. The new law will take effect just as the UK has launched two major plans—The National Cancer Plan for England, and The England Rare Diseases Action Plan 2026.

The Government of Canada and five partner organisations have committed more than CA$41 million to fund 19 cancer prevention research teams over 5 years. The announcement was made on Feb 26, 2026, at Princess Margaret Cancer Centre in Toronto by Marjorie Michel, Canada's Minister of Health. It is the single largest investment in cancer prevention research ever led by the Canadian Institutes of Health Research (CIHR).

On Feb 28, 2026, Indian Prime Minister Narendra Modi unveiled a national campaign to promote human papillomavirus (HPV) vaccination to prevent cervical cancer. During the 90-day drive, 11·5 million girls aged 14 years will be administered the vaccine for free at government-run health facilities across the country. “This is the largest free HPV vaccination campaign in history”, said WHO Director-General Tedros Adhanom Ghebreyesus (WHO, Geneva, Switzerland). After the current campaign ends, the Indian health ministry will integrate the HPV vaccine into the Universal Immunisation Programme (UIP) and make it available at government health facilities during routine immunisation days, Health Minister Jagat Prakash Nadda (New Delhi, India) announced while addressing a virtual press conference, along with Ghebreyesus, on March 5.

Presenting on behalf of a large international team, Martin Heidinger (DBM Hebelstrasse, Basel, Switzerland), showed results from a preplanned analysis of the TAXIS/OPBC-03 phase 3 trial. Axillary lymph node dissection (ALND) is the standard of care for patients with node-positive breast cancer after neoadjuvant chemotherapy or upfront surgery. The use of tailored axillary surgery (TAS) to reduce axillary tumour burden to a degree where radiotherapy might be able to control the remaining extent of disease could reduce morbidity.

The US Environmental Protection Agency (EPA) proposed changes to rollback safeguards against air emissions of ethylene oxide (EtO), a highly carcinogenic gas used to sterilise about half of all medical devices in the USA. Announced March 17, 2026, the proposed changes would, among other things, relax round-the-clock emissions monitoring requirements for about 90 commercial sterilisation facilities.

The Public Health Ministry in Thailand has planned to draft the country's first National Cancer Act, as new cancer cases and deaths from cancer remain high in the country.

Disruptions to pharmaceutical transport routes linked to the escalating conflict in the Middle East are raising alarms about the fragility of cancer medicine supply chains in low-income and middle-income countries, particularly across Africa. Routes commonly used to carry temperature-sensitive medicines—including chemotherapy drugs and other oncology supplies—have been affected as airlines and shippers avoid conflict zones, increasing costs and delaying deliveries. For patients already navigating fragile health systems, even short interruptions can have serious consequences.

Improved risk stratification in prostate testing could ensure effective resource allocation, according to results from the OPT Stockholm3 study. In the population-based study, Ugo Falagario and colleagues (University of Foggia, Foggia, Italy) assessed whether reflex testing with Stockholm3 after PSA testing could reduce the proportion of men referred for MRI versus a PSA-only pathway. The OPT Stockholm3 pathway invited all men in the Region Stockholm Gotland in 2024 (born in 1974; Stockholm3 testing if PSA ≥2 ng/mL and if Stockholm3 ≥15 MRI) and 2023 (born in 1973; MRI if PSA ≥3 ng/mL).

As we venture further into space and increasingly use low Earth orbit for in-space manufacturing, the potential for the development of innovative technologies appears to be infinite. For these discoveries, led by the National Aeronautics and Space Administration (NASA), international space agencies, and commercial companies, the International Space Station (ISS) provides a transformative research platform 250 miles above us in low Earth orbit. Although it might not be immediately obvious how research done hundreds of miles above our planet could be used to improve life terrestrially, studies in low Earth orbit have revealed accelerated stem-cell ageing; immune dysfunction; and genomic, epigenomic, and transcriptomic instability that set the stage for cancer initiation and progression.

Benmelstobart plus anlotinib showed longer progression-free survival than pembrolizumab plus placebo and no unexpected safety signals were reported, suggesting benmelstobart plus anlotinib as a potential first-line option in driver gene-negative, PD-L1-positive, advanced NSCLC. Longer term follow-up is needed to establish effects on overall survival.

In treatment-naive KRASG12C-mutated NSCLC, fulzerasib plus cetuximab showed encouraging activity with a favourable safety profile. The combination is currently being planned for investigation in a phase 3 study.

Perioperative sacituzumab govitecan plus pembrolizumab revealed a promising clinical complete response rate, without the occurrence of grade 4 or higher adverse events, allowing a bladder preservation with sustained remission in approximately 40% of patients.

This meta-analysis showed that people with melanoma who underwent SNB had a significantly reduced risk of death from melanoma and recurrence compared with those who did not. These findings are consistent with the only published randomised controlled trial and were robust on sensitivity analyses, indicating that SNB confers true survival and recurrence benefits.

177Lu-PSMA-617 showed promising response rates and delayed disease progression in patients with oligometastatic HSPC in this trial. In addition, most treatment-related adverse events were low grade.

Multicycle [177Lu]Lu-PSMA-617 and pembrolizumab showed encouraging activity with manageable toxicity that was consistent with [177Lu]Lu-PSMA-617 or pembrolizumab, and the combination might provide durable clinical benefit in a subset of patients.

We present new risk nomograms by PROMISE along with a simple table to prognosticate 3-year, 5-year, and 7-year overall survival in prostate cancer. PROMISE and PPP3 assessments are freely available online for global implementation.

The maximum tolerated dose was not reached with ifinatamab deruxtecan; however, one death due to treatment-related interstitial lung disease highlights the importance of prompt evaluation and careful management of patients who develop interstitial lung disease. Promising antitumour activity was observed across various solid tumours. These findings support further evaluation of ifinatamab deruxtecan in randomised controlled trials.

Understanding the frequency and nature of variants in cancer predisposition genes is important for planning of clinical services. Our analysis highlights the implications of more expansive genetic testing and the variant interpretation considerations necessary to yield benefit and avoid harm (eg, unnecessary surveillance) for patients.

These findings show that AI applied to routine histopathology can serve as a practical and scalable tool for guiding chemotherapy decisions in hormone receptor-positive, HER2-negative, early breast cancer. This approach has the potential to reduce unnecessary chemotherapy and broaden access to precision oncology, particularly in resource-limited settings where genomic testing remains unavailable or unaffordable.

Complete macroscopic resection is the key objective of cytoreductive surgery for peritoneal malignancy. However, heterogeneity in terminology and operative technique persists across centres and between surgical and gynaecological disciplines. This study sought to establish international consensus on the nomenclature of cytoreductive surgery procedures, key technical principles of peritonectomy procedures and visceral resections, and management of regional lymph nodes in the context of peritoneal malignancy.

Vaccine-preventable infections remain a major cause of morbidity and mortality in patients with cancer. The updated guideline for anti-infective vaccination strategies in patients with cancer of the German Society of Hematology and Medical Oncology Infectious Diseases Working Group was developed by a guideline panel of experts in internal medicine, haematology, medical oncology, and infectious diseases. For previously covered vaccinations, we included all publications in patients with cancer starting from 2017, as this was the data cutoff for the previous guideline, and for newly included vaccines all publications were reviewed.

Persistent inequities in cancer outcomes remain a defining challenge for global health systems, including in high-income countries. Despite advances across prevention, early detection, treatment, and survivorship, disparities persist, reflecting entrenched social and structural inequities. While equity is increasingly articulated within national and global cancer agendas, comparative analysis of how equity is conceptualised and operationalised in national cancer control planning remains limited.

Patient-reported outcomes (PROs) are increasingly recognised for their role in assessing tolerability in dose-finding oncology trials (DFOTs). However, analysis and reporting of PRO data within DFOTs are often unclear and inconsistent. OPTIMISE-AR (Incorporating Patient-Reported Outcomes in Dose-Finding Trials–Analysis Recommendations) establishes a practical toolkit supporting the statistical analysis, visualisation, and reporting of PRO data within DFOT publications. International, multidisciplinary, cross-sector statistical analysis and data visualisation working groups identified analytical and visualisation approaches for PROs data, addressing key DFOT PRO research objectives.

A 51-year-old man with advanced pancreatic cancer presented to General Hospital of Southern Theater Command (Guangzhou, China) in December, 2025, with a 3-week history of rapidly spreading, painful subcutaneous nodules (figure A), and bilateral knee pain. He was on maintenance oral tegafur after initial response to FOLFIRINOX. His knee pain, initially managed as gout given his history, was unresponsive to treatment. Skin biopsy revealed lobular panniculitis with neutrophilic infiltration and anucleate necrotic adipocytes (ghost cells), consistent with pyogenic panniculitis (figure B).

Up to three-quarters of people with haemophilia worldwide are estimated to be undiagnosed, with an even bigger gap predicted for other bleeding disorders. This astonishing statistic underlies the focus of this year's World Haemophilia Day, on April 17, on diagnosis: a first step to care. Even when people are diagnosed, there are substantial inequalities in access to treatment and bleeding prophylaxis in many parts of the world. 2026 could mark a crucial year for turning the tide on these issues, with the recent approval of a World Health Assembly (WHA) resolution on Global Action to Advance Health Equity for People with Hemophilia and Other Bleeding Disorders, which will be presented at the 79th WHA on May 18–23, 2026, for final adoption.

In 2024, WHO updated haemoglobin thresholds and revised the adjustments for altitude and smoking.1 The earlier elevation adjustments were established in 1989 and were based on a demographically limited subset of populations and did not adequately represent the diversity of global populations. The 2024 updated elevation adjustment was based on the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project, which leverages multinational surveys with broader geographical and demographic representation than previous methods.

In The Lancet Haematology, Dominik Dytfeld and colleagues1 report the findings from the phase 3 ATLAS trial, comparing carfilzomib–lenalidomide–dexamethasone with lenalidomide alone as maintenance therapy after autologous haematopoietic stem-cell transplantation (HSCT) in patients with newly diagnosed multiple myeloma. Lenalidomide monotherapy has long been the global standard of care in this setting, based on consistent improvements in progression-free survival and overall survival.2 With a median follow-up of nearly 6 years, carfilzomib–lenalidomide–dexamethasone maintenance significantly improved 4-year progression-free survival (67·5% [95% CI 56·2–76·4] vs 38·0% [27·6–48·2]; hazard ratio 0·46 [95% CI 0·30–0·70]) with a manageable safety profile.

The RESMAIN trial by Rudolf Stadler and colleagues, published in The Lancet Haematology, showed that resminostat maintenance therapy significantly prolonged median progression-free survival (median 8·3 months, 95% CI 4·2–15·7) compared with placebo (4·2 months, 2·8–6·4) in patients with advanced-stage mycosis fungoides or Sézary syndrome.1 These diseases are characterised by repeated cycles of remission and relapse. Therefore, progression-free survival does not carry the same clinical implications as in acute leukaemia or solid tumours, in which relapse is often associated with worse survival.

I would like to thank Takashi Miyachi and colleagues for their Correspondence regarding the RESMAIN trial. The most prevalent forms of cutaneous T-cell lymphoma are mycosis fungoides and its variants, as well as Sézary syndrome. According to the current guidelines, in the early stages of the disease, the recommended therapeutic approach is based on skin-directed therapies. In more advanced stages of the disease, the recommended treatment involves primarily non-toxic systemic drugs, such as pegylated interferon, bexarotene, and combinations with radiotherapy or extracorporeal photopheresis.

Olíva EN, Cottone F, Unni S, et al. Patient-reported outcomes in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia receiving standard chemotherapy plus quizartinib or placebo (QuANTUM-First): a global, randomised, placebo-controlled, phase 3 trial. Lancet Haematol 2026; 13: e169–80—In figure 2 of this Article, the two groups were incorrectly labelled “Q+stdCT” and “Q+stdCT” instead of “Q+stdCT” and “P+stdCT”. This correction has been made as of April 2, 2026.

Perrot A, Frenzel L. Maintenance intensification after autologous HSCT: refining selection. Lancet Haematol 2026; published online March 11. https://doi.org/10.1016/S2352-3026(26)00064-5—In this Comment, the title should have been Maintenance intensification after autologous HSCT: refining selection. This correction has been made as of March 19, 2026.

Dytfeld D, Wróbel T, Jamroziak K, et al. Carfilzomib, lenalidomide, and dexamethasone compared with lenalidomide treatment after autologous haematopoietic stem-cell transplantation in patients with multiple myeloma (ATLAS): primary analysis of a randomised, open-label, phase 3 trial. Lancet Haematol 2026; 13: e241–53—Anna Puła's affiliations should have been “Medical University of Lodz, Lodz, Poland” and “University of Chicago, Chicago, IL, USA”. Agnieszka Druzd-Sitek's and Prof Jan Walewski's affiliation should have been “Maria Skłodowska-Curie National Research Institute of Oncology, ERN EuroBloodNet, Warsaw”.

WHO has adopted a resolution to advance health equity for people with haemophilia and other bleeding disorders. Led by Armenia and co-sponsored by 12 countries across Europe, Asia, Africa, and the Americas, the resolution was approved by the WHO Executive Board (EB158) meeting on Feb 3, 2026, and aims to improve access to care and treatment worldwide. Armen Melkonyan, Head of International Relations at the Ministry of Health in Armenia, presented the resolution, which seeks to establish an international framework to improve care and treatment for people with haemophilia and other bleeding disorders.

Jayastu Senapati and Naval G Daver

I write on a day of unexpected personal and professional convergence. This past week, I spent long days in strategic discussions on enabling cell and gene therapy programmes—expanding access to advanced therapeutics and building infrastructure so that patients in our region might benefit from innovation at home rather than waiting for it to become available elsewhere. The work was forward-looking and ambitious. Yet I awoke today to news and sounds of interception explosions that, for the first time, felt unexpectedly and uncomfortably close to my new home, the United Arab Emirates.

Deucrictibant significantly reduced the severity of hereditary angioedema attacks compared with placebo; these results support continued investigation of antagonism of the bradykinin B2 receptor with an orally available agent as a potentially effective approach, with a safety profile similar to placebo, for on-demand treatment.

To the best of our knowledge, this trial provides the first clinical evidence and proof-of-concept for bradykinin B2 receptor antagonism as a therapeutic approach for the prevention of hereditary angioedema attacks and supports further investigation of oral deucrictibant for bradykinin-mediated angioedema.

Understanding the effect of anaemia requires unbiased and comparable estimates of anaemia burden. To our knowledge, we produced the first set of global estimates of anaemia burden by location, year, age, and sex using the WHO 2024 elevation adjustment method and compared them with estimates using the previous method. Policy makers should consider this modification when designing interventions to manage and prevent anaemia, particularly in regions most affected by changes in elevation adjustment.

The enhanced efficacy of carfilzomib–lenalidomide–dexamethasone treatment following autologous HSCT in patients with newly diagnosed multiple myeloma, assessed within a framework of de-escalation based on MRD status and individual risk, supports strategies for maintenance therapy intensification in this setting.

Haemophilia care has progressed through successive therapeutic revolutions, from plasma-derived and recombinant factor replacement to extended half-life products and non-factor therapies. The introduction of gene therapy, with currently approved approaches using adeno-associated viral vectors to deliver functional copies of the factor VIII or IX gene into hepatocytes, now represents the next paradigm shift: a one-time, irreversible intervention designed to restore endogenous factor production. Although early results are promising, the experience of transfusion transmitted infections reminds the haemophilia community that innovation must be matched by vigilance, transparency, and accountability.

Rebalancing agents represent a novel therapeutic class in haemophilia, designed to restore the deficient thrombin generation that underlies bleeding. Unlike factor replacement or factor VIII mimetic therapies, rebalancing agents act by downregulating natural anticoagulants. By partially inhibiting these physiological brakes of coagulation, they induce a controlled and reversible procoagulant shift. These agents have shown clinically meaningful reductions in bleeding rates across both haemophilia A and B, including in patients with inhibitors.

With the increasing adoption of posttransplant cyclophosphamide (PTCy) as graft-versus-host disease prophylaxis, survival outcomes after HLA-mismatched donor hematopoietic cell transplantation are now comparable to those achieved with HLA-matched donors. Shaffer, Lee, and Perales review how this paradigm shift influences donor selection decisions and provide illustrative case vignettes highlighting concepts applicable to different clinical scenarios.

VCAR33 is a donor-derived anti-CD33 chimeric antigen receptor-modified (CAR) T-cell developed for relapsed acute myeloid leukemia (AML) following allogeneic hematopoietic cell transplantation. Mushtaq et al report a phase 1/2 study of 15 adults with relapsed or measurable residual disease–positive AML or myelodysplastic syndrome with a generally manageable toxicity profile of mostly low-grade cytokine release syndrome, limited neurotoxicity, and one case of grade III graft-versus-host disease. There is a 20% response rate and evidence of in vivo expansion, supporting early anti-leukemic activity.

There is a critical need for targeted approaches to eliminate ABO-responsive B cells to enable ABO-incompatible solid organ transplantation. While anti-CD20 therapies such as rituximab are effective, they cause broad B-cell depletion and increase infection risk. Choi et al describe a T-cell–recruiting bispecific antibody–ligand conjugate that selectively eliminates blood group–responsive B cells, demonstrating depletion of A antigen–specific B cells in human peripheral blood mononuclear cells with efficacy comparable to rituximab while sparing bystander B cells, supporting further development toward human translation.

Oncogenic mutations in SF3B1 are among the most common lesions in myeloid malignancies and chronic lymphocytic leukemia, classically linked to aberrant splicing of protein-coding sequences. Sekrecki et al uncovered a previously unrecognized function, showing that mutant SF3B1 rewires noncoding mRNA splicing to drive malignant phenotypes while creating therapeutic vulnerabilities. Specifically, missplicing of DCAF16 increases its protein expression, suggesting the potential to exploit BRD4-targeting protein degraders in SF3B1-mutant disease. This work reframes SF3B1 biology by demonstrating that altered splicing of untranslated regions can promote gain-of-function effects and reveal new treatment strategies.

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy comprising multiple biologically distinct subgroups. Ranasinghe et al identified a new genome-wide significant risk locus for pan-AML, along with 3 additional loci associated with specific subgroups, including AML with chromosome 5 and/or 7 deletions and cytogenetically complex disease. They also show that variants linked to clonal hematopoiesis risk are similarly associated with AML. These findings refine our understanding of AML etiology and highlight shared genetic susceptibility with clonal hematopoiesis.

ANKRD26-related thrombocytopenia 2 (THC2) is a rare inherited platelet disorder caused by germline variants in the 5′ untranslated region of ANKRD26. Chen et al investigated defective megakaryopoiesis in THC2 by using single-cell transcriptomics and ex vivo functional profiling of bone marrow samples from 4 affected patients. They identified reproducible abnormalities in progenitor expansion and increased apoptosis of polyploid megakaryocytes, and they propose a novel mechanism in which centrosomal overexpression of ANKRD26 drives polyploid megakaryocyte apoptosis through JUNB-mediated induction of p21 transcription.

With increasing frontline use of blinatumomab for acute lymphoblastic leukemia (ALL), its impact on subsequent CD19 chimeric antigen receptor (CAR) T-cell therapy outcomes is a key clinical question. Srinagesh et al leveraged data collected by the Real-World Outcomes Collaborative of CAR-T in Adult ALL consortium for 271 adults, and they report that prior nonresponse to blinatumomab was associated with inferior survival after brexucabtagene in comparison to blinatumomab-naïve patients (12-month progression-free survival, 33% vs 60%; overall survival, 51% vs 72%). Notably, early CAR-T responses were uniformly high (∼90% complete remissions with or without hematologic recovery at day 28) regardless of prior exposure or response. These data highlight that resistance to blinatumomab may identify patients at higher risk of post–CAR T relapse despite excellent initial responses.

Fianlimab plus cemiplimab demonstrated modest clinical efficacy with an acceptable safety profile in patients with advanced malignancies across several tumor types mostly in treatment‐naive patients. Further investigation is warranted.

Tonsillar cancers carried the highest DALY burden among HPV‐associated OPCs in US men. Patients who were aged 65 years and older and were never vaccine‐eligible presented significant DALY increases across all cancer subsites, emphasizing the need for gender‐neutral HPV vaccination and catch‐up programs for high‐risk older men.

Long-term adverse events were rare and manageable among patients with alveolar soft part sarcoma (ASPS), which primarily affects adolescents and young adults, who received immunotherapy beyond the standard 2 years, according to results from a phase II clinical trial presented at the American...

New data from the American Medical Association (AMA) show physician burnout continuing to decline nationwide, but significant differences across medical specialties underscore the need for more targeted solutions within health systems.

The number of unique clinical trial sites in the United States with phase I studies for patients with non–small cell lung cancer (NSCLC) decreased by 44% from 2020 to 2024, showing a significant consolidation of studies to only high trial volume sites in the country, according to the results of a...

As reported in The Lancet by Lorusso et al, the phase III ROSELLA trial has shown an improvement in overall survival with the addition of relacorilant to nab-paclitaxel in patients with platinum-resistant ovarian cancer. Relacorilant is a selective glucocorticoid receptor antagonist that acts to...

In a Chinese phase II trial (EC-CRT-002) reported in the Journal of Clinical Oncology, Chen et al found that the addition of the anti–PD-1 monoclonal antibody tislelizumab without maintenance cycles to induction chemotherapy and concurrent chemoradiotherapy significantly improved progression-free...

In a French phase II study (IMHOTEP) reported in the Journal of Clinical Oncology, de la Fouchardière et al found that perioperative pembrolizumab was active in previously untreated resectable localized colorectal cancer with mismatch repair deficiency (dMMR)/microsatellite instability (MSI).

Researchers at The University of Texas MD Anderson Cancer Center have identified CD40 overexpression as a potential prognostic biomarker in angioimmunoblastic T-cell lymphoma (AITL), a rare subtype of non-Hodgkin lymphoma that is difficult to diagnose and treat. The results of their study were...

A population of patients with highly refractory follicular lymphoma achieved long-standing responses with few significant adverse events from odronextamab monotherapy, according to findings of the ELM-2 study. The study outcomes were published by Tessoulin et al in Clinical Lymphoma, Myeloma &...

In a Chinese phase II study (ABC) reported in the Journal of Clinical Oncology, Li et al found that the combination of the PD-L1 inhibitor adebrelimab, bevacizumab, and cisplatin or carboplatin showed high intracranial activity and progression-free survival in patients with triple-negative breast...

In a systematic review and meta-analysis reported in JAMA Oncology, Agrotis et al found that pretreatment MRI provided important prognostic information after radical prostatectomy in patients with prostate cancer.

Early-onset of immune checkpoint inhibitor (ICI)–related myocarditis was associated with an increased risk for myocarditis fatality, according to the results of a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2026 (Abstract 5212). The researchers suggested...

In a phase IA to IB trial reported in The New England Journal of Medicine, Heymach et al found that first-line zongertinib was active in patients with advanced or metastatic HER2-mutant non–small cell lung cancer (NSCLC).

Exposure to wildfire smoke was associated with a significantly increased risk of lung, colorectal, breast, bladder, and blood cancers, according to results from a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2026 (Abstract 6252).

Injecting the PD-1 inhibitor nivolumab directly into precancerous oral lesions led to reduction in lesion size and allowed some patients to avoid surgery, according to research from a phase I clinical trial (ClinicalTrials.gov identifier NCT05327270) presented at the American Association for Cancer ...

A biology-guided artificial intelligence model applied to routine pathology slides accurately predicted outcomes and response to immunotherapy in patients with metastatic non–small cell lung cancer (NSCLC), according to a study presented at the American Association for Cancer Research (AACR) Annual ...

A single infusion of the chimeric antigen receptor (CAR) T-cell therapy ciltacabtagene autoleucel led to a 100% measurable residual disease (MRD)-negativity rate in patients with high-risk smoldering multiple myeloma, according to results from CAR-PRISM, a phase II clinical trial, presented at the...

An artificial intelligence (AI) model using DNA methylation patterns was able to classify tumors of unknown origin with high accuracy, according to the results of a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2026 (Abstract 3869). 

Initial data from the phase I study of WEE1 inhibitor zedoresertib and PKMYT1 inhibitor lunresertib demonstrated an expected and manageable safety profile in patients with advanced solid tumors harboring CCNE1, FBXW7, or PPP2R1A gene alterations, according to findings from the MYTHIC trial...

Elisrasib, a next-generation KRAS G12C inhibitor, demonstrated disease control in a majority of patients with KRAS G12C–mutated non–small cell lung cancer (NSCLC), whether exposed to a prior KRAS G12C inhibitor or not, according to findings from an ongoing phase I/II clinical trial presented at the ...

As reported in JAMA Oncology by Richardson et al, a secondary analysis of the GAP70+ trial showed that treatment modifications and outcomes did not differ between older patients with advanced cancer who prioritized quality of life (QOL) vs those who preferred prolonging survival.

The investigational KRAS G12D inhibitor zoldonrasib had a favorable safety profile and induced antitumor activity in some patients with KRAS G12D–mutated non–small cell lung cancer (NSCLC) who were previously treated with chemotherapy and immunotherapy, according to preliminary findings from an...

Patients with advanced platinum-resistant ovarian cancer who had experienced disease progression on standard therapy exhibited clinical benefit when treated with the investigational antibody-drug conjugate (ADC) QLS5132, according to results from a phase I clinical trial (ClinicalTrials.gov...

ASCO has expanded its Targeted Agent and Profiling Utilization Registry (TAPUR™) study with two new developments:

Assessment of machine-learning models tested on Swedish registry data enabled more accurate melanoma diagnosis prediction, with added health-care code, age, sex, and medication information for improved performance, according to the results of a study published in Acta Dermato-Venereologica. 

Researchers have developed an artificial intelligence (AI) tool that can identify small groups of cells most responsible for driving aggressive cancers. The tool, called SIDISH, offers scientists a clearer path to designing targeted therapies by showing which cells inside a tumor are most strongly...

Right ventricle (RV) dysfunction is associated with poorer outcomes in heart failure with preserved ejection fraction (HFpEF). Females are more likely to have HFpEF but males have worse prognosis and resting RV function. The contribution of dynamic RV-pulmonary artery (RV-PA) coupling between sex and its impact on peak exercise capacity (VO2) in HFpEF is not known.

A Phase I, single-center investigation demonstrated that 8 weeks of antimycobacterial therapy improved sarcoidosis forced vital capacity (FVC). Safety and efficacy assessments have not been performed in a multicenter cohort.

All aspects of medical education were affected by the Novel Coronavirus Infectious Disease-19 (COVID-19) pandemic. Several challenges were experienced by trainees and programs alike due to the economic repercussions of the pandemic, how social distancing affected the delivery of medical education, testing and interviewing, how the surge of patients affected redeployment of personnel, potential compromise in core training and the overall impact on the wellness and mental health of trainees and educators.

In this meta-analysis of observational studies, RV dysfunction was associated with higher short-term and long-term mortality in sepsis and septic shock.

Legionella is an uncommon cause of CAP, occurring primarily from late spring through early autumn. Testing is uncommon, even among patients with risk factors, and many positive patients failed to receive empiric coverage for LP.

The nS classification could be used to provide a more accurate prognosis in patients with resected NSCLC. The nS is worth taking into consideration when defining nodal category in the forthcoming ninth edition of the staging system.

NLP successfully identified a large cohort with CC. Most patients were identified through NLP alone, rather than diagnoses or medications. NLP improved detection of patients nearly seven-fold, addressing the gap in ability to identify and characterize CC disease burden. Nearly all cases appeared to be managed in primary care. Identifying these patients is important for characterizing treatment and unmet needs.

Pulmonary arterial hypertension (PAH) is a rare disease and much of our understanding stems from single-center studies, which are limited by sample size and generalizability. Administrative data offer an appealing opportunity to inform clinical, research, and quality improvement efforts for PAH. Yet, there is currently no standardized, validated method to distinguish PAH from other subgroups of pulmonary hypertension (PH) within this data source.

A transparent DL algorithm improves on traditional clinical criteria to predict the need for MV in hospitalized patients, including in those with COVID-19. Such an algorithm may help clinicians optimize timing of tracheal intubation, better allocate resources and staff, and improve patient care.

To assess airway and lung parenchymal damage non-invasively in cystic fibrosis (CF), chest MRI has been historically out of the scope of routine clinical imaging due to technical difficulties such as the low proton density and respiratory and cardiac motion. However, technological breakthroughs have recently emerged to dramatically improve lung MRI quality (including signal-to-noise ratio, resolution, speed, contrast). At the same time, novel treatments have changed the landscape of CF clinical care.

Bronchoscopic lung volume reduction with one-way endobronchial valves is a guideline treatment option for patients with advanced emphysema, supported by extensive scientific data. Patients limited by severe hyperinflation, with a suitable emphysema treatment target lobe and with absence of collateral ventilation are the responders to this treatment. Detailed patient selection, a professional treatment performance, and dedicated follow-up of the valve treatment, including management of complications, are key ingredients to success.

Chronic Obstructive Pulmonary Disease (COPD) may cause profound dyspnea, functional impairment, and reduced quality of life. Available pharmacologic therapy provides suboptimal symptom improvement in many patients. Bronchoscopic lung volume reduction (BLVR), achieved with endobronchial valve (EBV) placement, can effectively improve dyspnea and functional status in appropriately selected patients. Operationalizing a safe and effective BLVR program requires appropriate oversight which can be achieved by a BLVR Nurse Coordinator (NC).

Empathy-based, stigma-reducing communication may lead to improved assessments of tobacco use and smoking cessation for patients with smoking-related cancers. These findings support the dissemination and further testing of a new ECS model for training OCPs in best practices for assessment of smoking history and engagement of patients who currently smoke in tobacco treatment delivery.

In clinical practice, reslizumab may have been initiated in response to heavy symptom burden and CAEs. Reslizumab was associated with improved clinical and patient-reported outcomes and significant reductions in asthma-related HRU.

Quantitative emphysema measured on LDCT of the chest can be leveraged to improve lung cancer risk prediction and help diagnose COPD in individuals who currently or formerly smoked undergoing lung cancer screening.

The ATOMIC trial has been widely celebrated as providing a positive result. However, when viewed with a lens of critical appraisal that considers issues related to overtreatment, treatment de-escalation, surrogacy, post-trial access to treatment and contributions of component, we argue that ATOMIC should not change clinical practice but rather form the basis for future trials that test de-escalation strategies.

Two recent phase II trials, INDIBLADE and SURE-02, challenge the long-standing paradigm of mandatory radical local therapy for muscle-invasive bladder cancer (MIBC). As increasingly potent systemic induction treatment strategies emerge, a key question arises: can induction therapy response guide omission of radical surgery and radiotherapy to enable preservation of an intact, functioning bladder in selected patients?

The burden of cancer therapy on patients’ time is often overlooked. Building on the ‘time toxicity’ literature, we introduce the concept of time budgeting, viewing patients’ time as a limited, measurable resource that can be managed through treatment selection, pathway design and trial protocols. We discuss the rationale, measurement challenges and implementation requirements to operationalize time budgeting in cancer care.

OS benefit with first-line datopotamab deruxtecan in advanced-stage TNBC

Rare lymphoproliferative and lymphomatous disorders occurring after chimeric antigen receptor (CAR) T cell therapy are garnering increased attention but remain incompletely characterized, complicating early recognition and management. This Review describes the spectrum of post-CAR T cell therapy lymphoproliferations reported so far, highlighting recurrent pathological and molecular features as well as factors implicated in promoting clonal expansion and/or malignant transformation, which might provide a framework to improve the diagnosis and management of these disorders.

Myelodysplastic neoplasms (MDS) comprise a heterogeneous group of malignancies that can lead to ineffective haematopoiesis, cytopenias and, potentially, progression to acute myeloid leukaemia. In this Review, the authors describe the epidemiology of MDS, which appears to be rising, as well as advances in diagnosis, risk stratification and clinical management.

Patients with meningioma, the most common type of intracranial primary tumour, have been traditionally managed with surgery and radiotherapy, although advances over the past decade have brought about promising novel treatment options. In addition, new molecularly driven classification tools can improve prognostic accuracy and guide personalized management decisions. The authors of this Review provide an integrated roadmap for meningioma care as well as a framework for ongoing and future research in this field.

Three recently published studies demonstrate the feasibility of modulating gut microorganisms using faecal microbiota transplantation (FMT) in patients receiving immune-checkpoint inhibitors (ICIs) in the first-line setting, expanding the evidence that FMT can augment response to ICIs. Herein, we discuss several opportunities for refining these efforts in order to increase the rigour and clinical benefit from microbiota modulation trials in oncology.

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With programs from Eisai and Hansoh Pharmaceutical in hand, Tortugas Neuroscience has emerged with hopes of delivering daily oral treatments to patients with central nervous system conditions.

An investigational cocktail was tied to a 0% overall response rate in patients with gastroesophageal cancer, but developers Agenus and MiNK Therapeutics aren’t giving up on the program just yet.

While Merck’s PD-1/VEGF asset appears to match the performance of Summit Therapeutics’ ivonescimab, the pharma’s Phase 1/2 readout in non-small cell lung cancer still leaves analysts with some questions moving into later-stage development.

Pivotal findings for the off-the-shelf cell therapy surpassed William Blair’s expectations and sent Allogene Therapeutics’ stock up more than 50% in pre-market trading Monday morning.

Darovasertib, in combination with crizotinib, more than doubled progression-free survival in a registrational trial, leading Truist analysts to declare a “best-in-class efficacy profile” for the PKC inhibitor.

Sanofi has faced questions about the potential of lunsekimig in eczema, with executives calling the clinical trial a “measured risk.”

PepGen’s lead candidate for myotonic dystrophy type 1 barely beat the placebo in a Phase 2 trial in terms of fixing incorrect gene splicing, but the biotech attributed the poor result to an outlier.

While tonlamarsen missed one of two co-primary endpoints, Kardigan says the drug has shown a clinically meaningful effect on blood pressure, supporting advancement into Phase 2b.

William Blair hailed a positive readout in cutaneous lupus erythematosus as a turning point for Biogen, while RBC Capital analysts called the results “another derisking step” for the company’s immunology and inflammation pipeline.

The lack of a dose-response effect could be due to the high number of dropouts in the higher-dose Winrevair arm and the relatively small study population, a discussant for Merck explained.

A triplet regimen comprising Merck’s Welireg and PD-1 blockbuster Keytruda and Eisai’s Lenvima flopped in a Phase 3 renal cell carcinoma trial.

The Phase 3 failure has prompted Gilead Sciences and Arcus Biosciences to terminate a mid-stage study of their TIGIT asset in lung cancer.

Novo Nordisk’s etavopivat elicited a 27% drop in vaso-occlusive crises and 48.7% hemoglobin response after 24 weeks, creating “separation amongst PK class candidates,” Truist analysts said on Monday. Novo plans to seek FDA approval in the back half of 2026.

In a difficult disease, Revolution Medicines achieved what the pancreatic cancer community has long desired: a significant improvement in survival. The Phase 3 results will support global regulatory filings.

Darovasertib, in combination with crizotinib, more than doubled progression-free survival in a registrational trial, leading Truist analysts to declare a “best-in-class efficacy profile” for the PKC inhibitor.

Sales of Amgen’s thyroid eye disease drug Tepezza have slowed, dipping 1% to $457 million in the fourth quarter of 2025.

Presentations at the 2026 meeting of the American Academy of Dermatology not only demonstrate the therapeutic potential of next-generation skin drugs but also shed light on how they might fare on the market.

Despite hitting its primary endpoint, Viridian’s thyroid eye disease antibody failed to ease eye bulging to the degree that analysts had been hoping for, and the biotech’s stock price fell by one-third.

Merck is eyeing a quick review for its lipid-lowering drug candidate enlicitide, which in December was awarded a Commissioner’s National Priority Voucher.

Missing one of its co-primary endpoints could make it difficult for Karyopharm Therapeutics to score conventional approval for Xpovio in myelofibrosis, according to Jefferies analysts.

As technology becomes more integrated and personalized, experts say the biggest opportunity in diabetes management is reducing everyday burdens.

With programs from Eisai and Hansoh Pharmaceutical in hand, Tortugas Neuroscience has emerged with hopes of delivering daily oral treatments to patients with central nervous system conditions.

A triplet regimen comprising Merck’s Welireg and PD-1 blockbuster Keytruda and Eisai’s Lenvima flopped in a Phase 3 renal cell carcinoma trial.

Moderna, Revolution Medicines and Zymeworks record wins in melanoma, lung and breast cancers, while BeOne swings and misses at head and neck cancer.

The Phase 3 failure has prompted Gilead Sciences and Arcus Biosciences to terminate a mid-stage study of their TIGIT asset in lung cancer.

An investigational cocktail was tied to a 0% overall response rate in patients with gastroesophageal cancer, but developers Agenus and MiNK Therapeutics aren’t giving up on the program just yet.

Novo Nordisk’s etavopivat elicited a 27% drop in vaso-occlusive crises and 48.7% hemoglobin response after 24 weeks, creating “separation amongst PK class candidates,” Truist analysts said on Monday. Novo plans to seek FDA approval in the back half of 2026.

While Merck’s PD-1/VEGF asset appears to match the performance of Summit Therapeutics’ ivonescimab, the pharma’s Phase 1/2 readout in non-small cell lung cancer still leaves analysts with some questions moving into later-stage development.

In this episode of Denatured, you’ll be hearing from Edoardo Negroni, co-founder & managing partner at AurorA-TT and Naveed Siddiqi, senior partner, Venture Investments at Novo Holdings. We debate whether Europe’s world-class science can be matched by a truly integrated venture ecosystem—and what it would take, in practice, to get there.

Despite exceptional regional hubs and research strength, investors say Europe still needs more integrated incubators, smarter regulation and broader pools of patient capital to keep breakthrough companies growing at home.

On March 25, 2026, the Food and Drug Administration approved relacorilant (Lifyorli, Corcept Therapeutics Inc.), a glucocorticoid receptor antagonist, in combination with nab-paclitaxel for the treatment of adults with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to three prior systemic treatment regimens, at least one of which included bevacizumab.

On March 20, 2026, the Food and Drug Administration approved nivolumab (Opdivo, Bristol Myers Squibb Company) with doxorubicin, vinblastine, and dacarbazine (AVD) for adult and pediatric patients 12 years and older with previously untreated, Stage III or IV classical Hodgkin lymphoma (cHL).

On March 5, 2026, the Food and Drug Administration approved teclistamab (Tecvayli, Janssen Biotech, Inc.) in combination with daratumumab hyaluronidase-fihj for adult patients with relapsed or refractory multiple myeloma who have received at least one prior line of therapy including a proteasome inhibitor and an immunomodulatory agent. 

On February 26, 2026, the Food and Drug Administration granted accelerated approval to zongertinib (Hernexeos, Boehringer Ingelheim Pharmaceuticals, Inc.), a kinase inhibitor, for an expanded indication for adults with unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain (TKD) activating mutations, as detected by an FDA-authorized test.

On February 24, 2026, the Food and Drug Administration granted traditional approval to encorafenib (Braftovi, Array BioPharma Inc., a subsidiary of Pfizer Inc.) in combination with cetuximab and fluorouracil-based chemotherapy for the treatment of adult patients with metastatic colorectal cancer (CRC) with a BRAF V600E mutation, as detected by an FDA-authorized test. Encorafenib received accelerated approval in combination with cetuximab and mFOLFOX6 for metastatic colorectal cancer with BRAF V600E mutation in 2024. 

On February 19, 2026, the Food and Drug Administration approved acalabrutinib (Calquence, AstraZeneca) tablets and capsules in combination with venetoclax (Venclexta, AbbVie Inc. and Genentech Inc.) for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

On February 10, 2026, the Food and Drug Administration approved pembrolizumab (Keytruda, Merck) as well as pembrolizumab and berahyaluronidase alfa-pmph (Keytruda Qlex, Merck) in combination with paclitaxel, with or without bevacizumab, for adult patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal carcinoma whose tumors express PD-L1 (CPS≥1) as determined by an FDA-authorized test, and who have received one or two prior systemic treatment regimens.

On January 27, 2026, the Food and Drug Administration approved daratumumab and hyaluronidase-fihj (Darzalex Faspro, Janssen Biotech, Inc.) in combination with bortezomib, lenalidomide, and dexamethasone (VRd) for adults with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant (ASCT).

On December 17, 2025, the Food and Drug Administration approved amivantamab and hyaluronidase-lpuj (Rybrevant Faspro, Janssen Biotech, Inc.) for subcutaneous injection for adult patients across all indications approved for the intravenous formulation of amivantamab (Rybrevant, Janssen Biotech, Inc.). See the prescribing information for the specific indications.

On December 17, 2025, the Food and Drug Administration approved rucaparib (Rubraca, pharmaand GmbH) for adults with a deleterious BRCA mutation (BRCAm) (germline and/or somatic)-associated metastatic castration-resistant prostate cancer (mCRPC) previously treated with an androgen receptor-directed therapy. Patients should be selected for therapy using an FDA-approved companion diagnostic (CDx).

On December 15, 2025, the Food and Drug Administration approved fam-trastuzumab deruxtecan-nxki (Enhertu, Daiichi Sankyo, Inc.) in combination with pertuzumab for the first-line treatment of adults with unresectable or metastatic HER2-positive (IHC 3+ or ISH+) breast cancer as determined by an FDA-approved test.

On December 12, 2025, the Food and Drug Administration approved niraparib and abiraterone acetate (Akeega, Janssen Biotech, Inc.) with prednisone for adults with deleterious or suspected deleterious BRCA2-mutated (BRCA2m) metastatic castration-sensitive prostate cancer (mCSPC), as determined by an FDA-approved test.

On December 4, 2025, the Food and Drug Administration approved lisocabtagene maraleucel (Breyanzi, Juno Therapeutics, Inc., a Bristol-Myers Squibb Company) for adults with relapsed or refractory marginal zone lymphoma (MZL) who have received at least two prior lines of systemic therapy

On December 3, 2025, the Food and Drug Administration granted traditional approval to pirtobrutinib (Jaypirca, Eli Lilly and Company) for adults with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who have previously been treated with a covalent BTK inhibitor. In 2023, FDA granted accelerated approval to pirtobrutinib for adults with CLL/SLL who have received at least two prior lines of therapy, including a BTK inhibitor and a BCL-2 inhibitor.

On November 25, 2025, the Food and Drug Administration approved durvalumab (Imfinzi, AstraZeneca) with fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy as neoadjuvant and adjuvant treatment, followed by single agent durvalumab, for adults with resectable gastric or gastroesophageal junction adenocarcinoma (GC/GEJC).

On November 21, 2025, the Food and Drug Administration approved pembrolizumab (Keytruda, Merck) or pembrolizumab and berahyaluronidase alfa-pmph (Keytruda Qlex, Merck) with enfortumab vedotin-ejfv (Padcev, Astellas Pharma) as neoadjuvant treatment followed by adjuvant treatment after cystectomy for adults with muscle invasive bladder cancer (MIBC) who are ineligible for cisplatin.

On November 19, 2025, the Food and Drug Administration granted traditional approval to tarlatamab-dlle (Imdelltra, Amgen Inc.) for adults with extensive stage small cell lung cancer (ES-SCLC) with disease progression on or after platinum-based chemotherapy. Tarlatamab-dlle received accelerated approval for this indication in 2024.

On November 19, 2025, the Food and Drug Administration granted accelerated approval to sevabertinib (Hyrnuo, Bayer HealthCare Pharmaceuticals Inc.), a kinase inhibitor, for adults with locally advanced or metastatic, non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain (TKD) activating mutations, as detected by an FDA-approved test, and who have received a prior systemic therapy.

On November 19, 2025, the Food and Drug Administration granted traditional approval to daratumumab and hyaluronidase-fihj (Darzalex Faspro, Janssen Biotech Inc.) with bortezomib, cyclophosphamide, and dexamethasone (VCd) for newly diagnosed light chain (AL) amyloidosis. FDA granted accelerated approval for this indication in 2021.

On November 19, 2025, the Food and Drug Administration approved selumetinib (KOSELUGO, AstraZeneca Pharmaceuticals LP) for adults with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (PN). FDA previously approved selumetinib capsules and granules for pediatric patients 1 year of age and older for this indication.

On November 18, 2025, the Food and Drug Administration approved epcoritamab-bysp (Epkinly, Genmab US, Inc.) with lenalidomide and rituximab for relapsed or refractory follicular lymphoma (FL). The FDA also granted traditional approval to epcoritamab-bysp as monotherapy for relapsed or refractory FL after two or more lines of systemic therapy (epcoritamab-bysp was granted accelerated approval for this indication in 2024). 

On November 13, 2025, the Food and Drug Administration approved Poherdy (pertuzumab-dpzb, Shanghai Henlius Biologics Co. Ltd.) as an interchangeable biosimilar to Perjeta (pertuzumab, Genentech Inc.). This is the first approval of a biosimilar for Perjeta.

On November 13, 2025, the Food and Drug Administration approved ziftomenib (Komzifti, Kura Oncology, Inc.), a menin inhibitor, for adults with relapsed or refractory acute myeloid leukemia (AML) with a susceptible nucleophosmin 1 (NPM1) mutation who have no satisfactory alternative treatment options.

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